Everything you need to know about polynucleotides

A new generation of regenerative aesthetics

In the world of modern anti-aging medicine, more and more attention is drawn to treatments that do not change the natural features of the face, but instead encourage the skin to regenerate itself. This is precisely why polynucleotides are one of the most interesting innovations in regenerative aesthetics in recent years.

Unlike procedures that primarily add volume or temporarily correct certain changes, polynucleotides aim to improve skin quality by stimulating natural regenerative processes.

Their popularity is growing worldwide because they fit into the modern trend of natural rejuvenation and preserving an authentic appearance.

What are polynucleotides?

Polynucleotides are biologically active chains of nucleotides — molecules that are the basic building blocks of DNA and RNA.

In aesthetic medicine, specially purified polynucleotides are used that have the ability to support tissue regeneration, improve cell communication and stimulate the skin’s renewal processes. The scientific literature describes them as biostimulators with the potential to improve skin texture, hydration, elasticity and the quality of the dermis.

How do they act on the skin?

With ageing, the activity of fibroblasts — the cells responsible for producing collagen and elastin — decreases.

Polynucleotides act by:

• stimulating fibroblast activity
• encouraging collagen synthesis
• supporting the creation of elastin
• improving skin hydration
• contributing to the regeneration of damaged tissue
• reducing oxidative stress
• supporting the skin’s natural recovery processes

Their goal is not to change the anatomy of the face, but to improve the quality of the skin from within. This is precisely why they are often classed among regenerative or biostimulating treatments.

What benefits can polynucleotides provide?

Clinical studies indicate that the application of polynucleotides can contribute to:

• improved skin texture
• increased elasticity
• better hydration
• reduced visibility of fine lines
• a more even complexion
• improved skin quality around the eyes
• skin regeneration after aesthetic procedures

Systematic reviews of the available literature show promising results in reducing wrinkles, improving skin tone and increasing patient satisfaction after treatment.

How do they differ from hyaluronic fillers?

One of the most common questions is whether polynucleotides are the same as fillers.

The answer is — no.

Hyaluronic fillers primarily serve to replace volume and shape certain areas of the face.

Polynucleotides have a different mechanism of action. They do not add volume but encourage tissue regeneration and improve skin quality through biological processes that take place over the following weeks and months.

For this reason they are often used in patients who want more natural results and improved skin quality without changing the appearance of the face.

Who is a candidate for the treatment?

Polynucleotides can be an interesting option for people who notice:

• the first signs of skin ageing
• loss of glow and tone
• fine lines
• dehydrated skin
• the effects of photo-damage
• a tired appearance in the eye area
• a general decline in skin quality

They are also often used as part of a broader regenerative anti-aging plan that may include microneedling, laser procedures and other treatments to stimulate collagen.

When are results visible?

Unlike procedures that provide an instant effect, the results of polynucleotides develop gradually.

Most patients notice:

• better hydration after a few weeks
• gradual improvement in skin texture
• greater elasticity over the following months
• a naturally refreshed look without sudden changes

This approach corresponds to the philosophy of regenerative aesthetics, where the goal is the long-term improvement of skin quality rather than an instant transformation of appearance.

Are polynucleotides safe?

Studies to date point to a favourable safety profile for polynucleotide treatments.

The most commonly reported reactions include:

• transient redness
• mild swelling
• tenderness at the injection site
• small bruises

These reactions usually resolve spontaneously over a few days. Nevertheless, as with all medical procedures, the treatment should only be carried out after a professional examination and assessment. Scientific reviews emphasise that further research is needed to define optimal protocols and long-term effects more precisely.

The future of natural rejuvenation

A growing number of experts believe that regenerative aesthetics is the next phase in the development of anti-aging medicine.

Polynucleotides fit perfectly into this concept because they do not aim to change appearance, but to improve skin quality through support for its natural biological functions.

Because of their ability to stimulate fibroblasts, support collagen synthesis and contribute to tissue regeneration, polynucleotides are becoming an important part of modern anti-aging protocols.

Conclusion

Polynucleotides are an innovative regenerative approach to skin rejuvenation focused on the quality, health and long-term vitality of the skin.

Their ability to encourage natural renewal processes, improve hydration and stimulate the creation of collagen makes them one of the most promising options in modern anti-aging medicine.

For patients who want natural, subtle and gradual results, polynucleotides are an interesting step towards a new era of regenerative aesthetics.

Learn more about the polynucleotide treatment or view all our anti-aging treatments.

Scientific references

1. Lampridou S. et al. The Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic Review (2025).
2. Lee K.W.A. et al. Polynucleotides in Aesthetic Medicine: A Review of Current Practices and Perceived Effectiveness (2024).
3. Rho N.K. et al. Evidence-Based Applications of Polynucleotides in Aesthetic Medicine (2026).
4. Polynucleotides and Polydeoxyribonucleotides in Dermatology: A Narrative Review (2025).
5. Ahmadi M. The Efficacy of Polynucleotide Injections in Aesthetic Medicine (review article).
6. Lampridou S. et al. Clinical outcomes regarding wrinkles, elasticity and skin quality.
7. Contemporary regenerative medicine perspectives on polynucleotides and fibroblast stimulation.
8. Current evidence regarding safety and clinical application of polynucleotides in regenerative aesthetics.